A number of AD brain organoid models have also been used as platforms to assess the efficacy of pharmacological agents in disease progression. Three-dimensional (3D) brain organoid systems generated from human pluripotent stem cells (hPSCs) have demonstrated considerable potential in recapitulating key features of AD pathophysiology, such as amyloid plaque- and neurofibrillary tangle-like structures.
Human neurodegenerative diseases, such as Alzheimer’s disease (AD), are not easily modeled in vitro due to the inaccessibility of brain tissue and the level of complexity required by existing cell culture systems. 3Department of Neurosurgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.21st Department of Neurology, AHEPA University Hospital, Thessaloniki, Greece.1Laboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.Angelos Papaspyropoulos 1*, Magdalini Tsolaki 2, Nicolas Foroglou 3 and Anastasia A.
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